Identifying protein phosphorylation, however, has proven to be a formidable challenge. Identifying such events will be critical in understanding many different diseases and pivotal in determining therapeutic targets for future drug development. On a larger scale, changes in the phosphorylation of specific proteins have been implicated in a variety of human diseases and because of this, there is an enormous amount of interest in the development of methods to identify protein phosphorylation on a global scale in the hope of unveiling phosphorylation events that are specific to a disease state. Due to the wide spectrum of changes that phosphorylation can impart to a protein, it is no surprise that this post-translational modification has been implicated in numerous biological processes. Protein phosphorylation has been shown to be an important post-translational modification, regulating activities as diverse as protein-protein interactions, enzymatic activity, subcellular localization, and ubiquitin-mediated degradation 1.
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